The BAF complexes are known to be important for development in mammals, and are also frequently mutated in cancers, including cancers that originate from B lymphocytes, which are antibody-producing cells in our body.
The turning on of inflammatory signatures in the absence of Arid1a was a really surprising finding, considering that the BAF complexes are primarily known to turn on and not turn off gene expression.
In the absence of this complex, inflammatory myeloid cells, which are typically not found in secondary lymphoid tissues, begin to accumulate at these sites and lead to disruption of immune responses.
Collection
[
|
...
]