"In our previous work, we reported findings showing that the protein HDAC3 is extremely important for lung cancer growth in two different in vivo models of KRAS-driven lung adenocarcinoma" - Lillian Eichner, PhD, highlighting the critical role of HDAC3 in lung cancer.
"By employing RNA sequencing, investigators found that HDAC3 in lung tumor cells regulates genes responsible for recruitment of T-cells - immune fighter cells that are critical effectors of immunotherapies." - A significant finding that links HDAC3 to immune response.
"Investigators administered a combination therapy of the HDAC3-blocking drug entinostat and the cancer drug trametinib to mice harboring KRAS mutant lung tumors and found that helpful tumor-fighting T-cells increased in quantity within the lung tumors." - An important step towards effective lung cancer treatments.
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