The article examines the role of the gut microbiota in vaccine responses, particularly focusing on early-life antibiotic exposure and its implications for immunization. Evidence suggests that antibiotics can impair antibody responses, especially to adjuvanted vaccines. A prospective study involving healthy infants revealed that antibiotic exposure during infancy correlates with lower antibody responses. The findings underscore a need to consider the timing and impact of antibiotics on immune development, as they appear vital for optimizing vaccination strategies in at-risk populations.
Our study highlights the significant impact of early-life antibiotic exposure on the immune responses of infants to various vaccines, ultimately influencing their long-term health.
The findings demonstrate that cumulative antibiotic exposure in the first year correlates with diminished antibody responses to vaccinations, suggesting critical windows for immune development.
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