In San Francisco, mpox cases increased in summer 2025, rising from one case per month to 10 in July and three more in August. Most cases were among individuals receiving both doses of the Jynneos vaccine. Health officials noted that these cases typically remain mild, with no severe infections requiring hospitalization. The recent uptick is modest compared to previous years and aligns with historical summer and fall increases linked to community events. Vaccination is still encouraged, as infections can still occur post-vaccination even if rare.
Most 2025 cases in San Francisco had been in people who had received both doses of the mpox vaccine, Jynneos. This highlights that vaccination does not guarantee complete immunity.
This increase in mpox cases is not a cause for alarm, as it's small. We've seen a similar trend of summer and fall surges since 2022, often linked to larger events.
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