The article discusses new findings on a specific subset of antigen-presenting cells (APCs) required for the differentiation of food- and microbiota-specific T regulatory cells (pTreg). This subset, identified as Prdm16+ RORt+ tolerizing dendritic cells (tolDC), is crucial for establishing oral tolerance. These cells originate from myeloid lineage and share epigenetic characteristics with classical dendritic cells. The research highlights that genetic alterations in tolDC lead to an increase in food antigen-specific T helper 2 cells, compromising immune tolerance in conditions like asthma and food allergies.
Our findings identify a crucial subset of antigen-presenting cells (APCs) that is indispensable for developing food- and microbiota-specific T regulatory cells, essential for oral tolerance.
These novel myeloid-originated APCs are characterized by the expression of Prdm16 and RORt transcription factors, distinguishing them from ILC3 and revealing their role in immune regulation.
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