The San Francisco 49ers will face the Denver Broncos in their preseason opener on Saturday at Levi's Stadium. Starters, including Brock Purdy, are likely to sit out, providing an opportunity to assess their remade defense with young players Alfred Collins and C.J. West. First-round pick Mykel Williams will miss the game due to a knee injury suffered in practice. Backup quarterback Mac Jones and third-stringer Carter Bradley are expected to see significant playing time as the team approaches the regular-season opener against Seattle less than a month away.
The San Francisco 49ers will play the Denver Broncos in their first preseason game of the 2025 season at Levi's Stadium, scheduled for Saturday at 5:30 p.m. PT.
Starters, including Brock Purdy, are likely to sit out most of the game, providing a chance to evaluate their remade defense including young linemen Alfred Collins and C.J. West.
Mykel Williams, a first-round defensive end, suffered a knee injury during practice and is expected to miss the game.
Backup quarterback Mac Jones and new third-stringer Carter Bradley will see significant action as the team prepares for the regular-season opener.
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