NINJ1 acts as a crucial protein that facilitates cell rupture during certain types of cell death, associated with diseases. The study emphasizes the cell membrane's role as a dynamic structure responding to mechanical forces, rather than merely serving as a protective barrier. Under sufficient physical stress, cells can experience catastrophic ruptures that release inflammatory substances. This research elucidates the response of NINJ1 to mechanical stress and investigates the factors determining its activation threshold, shedding light on the mechanisms behind cell death associated with infections and other conditions.
NINJ1 is essential for cells to break open during certain cell death processes. This membrane protein reacts to mechanical stress which leads to cell rupture.
The cell membrane serves as both a barrier and a defense system against mechanical forces. It can be compromised under severe stress, leading to the release of cellular contents.
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