"It's not simply the accrual of excess fat that leads to disease. It's a change in the actual function and the capacity of the energy center within the cell to work properly. The circadian rhythm is the body's own internal 24-hour clock that regulates the sleep-wake cycle, hormone levels and metabolism, among other systems throughout the body."
"At the molecular level, circadian rhythm is regulated by a transcription-translation feedback loop, in which proteins including CLOCK and BMAL1 regulate the expression of myriad clock genes supporting proper circadian rhythm. These clocks are present in nearly every tissue and organ in the body, including adipose tissue."
"Previous work led by Bass had shown that a high-fat diet can lead to disruption of circadian rhythm and that this disruption contributes to obesity, metabolic disease and even cancer. Precisely how the circadian clock regulates energy balance in cells and throughout the body, however, has remained unclear."
Northwestern Medicine researchers discovered that disruptions in circadian rhythm impair metabolic function in fat cells, revealing molecular mechanisms underlying obesity and metabolic disease. The circadian rhythm, the body's 24-hour internal clock, regulates sleep-wake cycles, hormone levels, and metabolism through proteins like CLOCK and BMAL1 that control clock genes in nearly every tissue. Previous research showed high-fat diets disrupt circadian rhythm, contributing to obesity and disease, but the precise mechanisms remained unclear. Scientists isolated mitochondria—the energy centers within cells—to investigate how circadian clocks regulate cellular energy balance and metabolism throughout the body.
Read at News Center
Unable to calculate read time
Collection
[
|
...
]