Conjugation serves as a key mechanism of horizontal gene transfer among bacteria, facilitating rapid gene evolution and contributing to the spread of antimicrobial resistance.
The process begins with the relaxosome assembling at the oriT, which is crucial for the initiation of the conjugation and subsequent transfer of the DNA strand.
Certain plasmid genes, particularly those in the leading region, are vital for the successful establishment of the plasmid during its entry into the recipient cell.
Unique F rpo promoters allow early gene expression in the recipient cell, enabling the incoming single-stranded DNA to be effectively utilized by the host.
#horizontal-gene-transfer #antimicrobial-resistance #conjugation #bacterial-evolution #plasmid-dynamics
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