"AlphaGenome predicts how mutations interfere with the way genes are controlled, changing when they are switched on, in which cells of the body, and whether their biological volume controls are set to high or low. Most common diseases that run in families, including heart disease and autoimmune disorders, as well as mental health problems, have been linked to mutations that affect gene regulation, as have many cancers, but identifying which genetic glitches are to blame is far from straightforward."
"The researchers trained AlphaGenome on public databases of human and mouse genetics, enabling it to learn connections between mutations in specific tissues and their impact on gene regulation. The AI can analyse up to 1m letters of DNA code at once and predict how mutations will affect different biological processes. The DeepMind team believes the tool will help scientists map out which strands of genetic code are most essential for the development of particular tissues, such as nerve and liver cells,"
AlphaGenome predicts how mutations interfere with gene control, altering when genes are switched on, which cell types express them, and their expression levels. The AI was trained on public human and mouse genetics databases to learn links between tissue-specific mutations and regulatory outcomes. The model can analyze up to one million DNA letters at once and forecast impacts on biological processes. AlphaGenome can map genomic regions essential for development of specific tissues, identify mutations that drive cancers and familial diseases, and enable design of novel DNA sequences to support targeted gene therapies and experimental manipulation.
Read at www.theguardian.com
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