The development of general methods that enable rapid synthesis of a broad range of organic compounds is paramount for drug discovery and related applications.
Al Zubaydi et al. introduce a general method for a challenging type of cross-coupling, particularly effective for linking flexible 3D aliphatic fragments.
This new cross-coupling reaction enhances the variety of compounds chemists can synthesize, which is crucial for finding effective 'Goldilocks' molecules.
The successful linking of aliphatic fragments through this new method opens valuable pathways for pharmaceutical research and compound library exploration.
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