Ambros and Ruvkun's discovery unveiled a groundbreaking class of microRNA, establishing a vital principle of gene regulation that is indispensable for the growth and function of multicellular organisms, including humans. This discovery has significant implications as it helps to clarify the complexities of cellular specialization, demonstrating how identical genes can lead to diverse cell types like muscle and nerve cells, ultimately enhancing our understanding of biology and disease.
Thomas Perlmann, secretary of the Nobel committee for physiology, described his early morning phone call to Ruvkun, capturing a moment of excitement as he shared the joyful news of their Nobel Prize win. Perlmann humorously noted the difficulty he faced in waking Ruvkun, whose initial fatigue soon turned to enthusiasm upon hearing about their exemplary recognition for contributions that reshaped our understanding of gene regulation.
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