Cholinergic modulation of dopamine release drives effortful behaviour - Nature
Dopamine release in the nucleus accumbens scales with prior effort for identical rewards, likely via local modulation of DA axon terminals involving acetylcholine.
New Research Suggests We Can Train Years Off Our Brains
Specific rigorous speed-training online exercises upregulate acetylcholine production, reversing a decade-long decline in 10 weeks and enhancing cognition; casual games show no benefit.
Mental exercise can reverse a brain change linked to aging, study finds
Rigorous daily cognitive training for 10 weeks increased acetylcholine by 2.3% in an attention-memory brain region, reversing about a decade of normal age-related decline.