Science
fromNature
5 days agoDaily briefing: How the brain locks in long-term memories
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Recall transiently destabilizes memories, which require re-stabilization to become long-lasting. Despite its importance in human cognition and neuropsychiatric disorders6,7, the mechanisms that specifically stabilize memories of critical experiences-those that are essential for survival and frequently marked by emotional salience and repetition-remain incompletely understood. Memory traces are linked to specialized neuronal ensembles (neuronal engrams), which include neuronal populations that become Fos+ during both initial and repeated experiences8.