N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that mediate excitatory neurotransmission throughout the brain1. As obligate heterotetramers, their activation requires the binding of both glycine and glutamate2. Although recent structural studies have provided insights into endogenous receptors from select brain regions3, most previous work has relied on recombinant receptors and engineered constructs, which limits our understanding of native NMDARs across the whole brain.
Marburg virus (MARV) is a filovirus that causes a severe and often lethal hemorrhagic fever1,2. Despite the increasing frequency of MARV outbreaks, no vaccines or therapeutics are licensed for use in humans. Here, we designed mutations that improve the expression, thermostability, and immunogenicity of the prefusion MARV glycoprotein (GP) ectodomain trimer, which is the sole target of neutralizing antibodies and vaccines in development38.
Author Correction: Structures of -synuclein filaments from multiple system atrophy Author Correction Published: 22 October 2025 Manuel Schweighauser orcid.org/0000-0002-1848-16101 na1, Yang Shi orcid.org/0000-0003-1579-75611 na1, Airi Tarutani2,3, Fuyuki Kametani orcid.org/0000-0001-9125-70012, Alexey G. Murzin1, Bernardino Ghetti orcid.org/0000-0002-1842-80194, Tomoyasu Matsubara orcid.org/0000-0002-7559-82845, Taisuke Tomita orcid.org/0000-0002-0075-59433, Takashi Ando6, Kazuko Hasegawa7, Shigeo Murayama5, Mari Yoshida8, Masato Hasegawa2, Sjors H. W. Scheres orcid.org/0000-0002-0462-65401 na2 & Michel Goedert orcid.org/0000-0002-5214-78861 na2 Nature (2025)Cite this article Cryoelectron microscopy Neurodegeneration Correction to: Nature https://doi.org/10.1038/s41586-020-2317-6 Published online 27 May 2020
Working on that timescale has long stymied biologists, but the rapid evolution of time-resolved cryo-electron microscopy (TR cryo-EM) over the past several years has made it possible to reconstruct dynamic processes with near-atomic detail.