#preclinical-testing

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#ai-drug-discovery #antibiotic-resistance #de-novo-molecular-design #organoids #stem-cells #drug-development
Medicine
fromFast Company
3 days ago

MIT drug hunters are using AI to design completely new antibiotics

AI-generated de novo molecular design produced millions of novel compounds and yielded AI-designed antibiotics that cleared drug-resistant infections in mice.
fromenglish.elpais.com
4 weeks ago

Hans Clevers, biomedical scientist: If I had colon cancer, I could grow my own tumor, test it with drugs, and see which one eliminates it'

Until now, preclinical trials relied primarily on two-dimensional cell cultures and animal models, which often failed to accurately replicate human biology. Since 2023, the U.S. Food and Drug Administration (FDA) has not required animal testing, thanks in part to organoids, which Hans Clevers (Eindhoven, 68 years old), professor of molecular genetics at Utrecht University, has been researching since the beginning of the century.
Science
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