#sequencing

#sequencing

"It had its own biography, its own deep history. It seemed like an archaeological site between covers," recalls Stinson, who is now a medievalist at North Carolina State University in Raleigh.

Using CRISPR-Cas9 and adeno-associated virus (AAV)-mediated homology-directed repair, we targeted CAR integration into the endogenous human TCR alpha locus (TRAC). TRAC-CAR T cells display dynamic CAR expression that delays exhaustion and improves tumour control in xenograft and immunocompetent models. This work has been critical for the development of allogeneic CAR T cell therapy, as it disrupts the TCR after transgene insertion—a necessary step to limit graft-versus-host disease.

Ushering in the Golden Age of Innovation is about more than just winning the global tech race - it's about securing the safety and prosperity of our country for generations to come. Our bill is an important step in this effort and will better ensure the United States has the infrastructure in place to lead the 21st century.

It was another detail that the rest of the family apparently knew but had never told me; they thought I already knew. The biology mattered less to me than the secret. Dad had been adopted, it turned out. A classic affliction of the 1950s, in which young, unmarried couples were forced to give away their newborn babies.

Scientists have long known that vast colonies of bacteria, viruses and other microorganisms—a population collectively called the microbiome—live on and inside the human body. But how they influenced our health was long a mystery. In just the past few years, we've learned that myriad factors, from the food that we consume to the amount of time that we spend sleeping to our genes to our home, all affect our microbiome.

The strategy could be fruitful: If unidentified DNA evidence can be connected to someone - even a distant relative - in a common genealogy database, it would give investigators more information and possibly lead to a suspect in Guthrie's kidnapping in Arizona. "It's a fantastic tool," said Ruth Ballard, a geneticist in California who specializes in DNA and has testified in hundreds of court cases. "If it's a good quality sample and they're able to get a profile, they could find a hit on that fairly quickly."

Before treatment began, participants underwent neuroimaging. Instead of relying on a single modality, the researchers fused structural connectivity (how regions are physically wired) with functional connectivity (how regions co-activate at rest). The goal was not to throw every possible feature at a black box, but to learn a constrained pattern-what the authors call structure-function "covariation"-that carries the most predictive signal for outcome. In other words, the model tries to find the smallest set of connections that meaningfully forecasts symptom change.

Scientists in the laboratory of Rendong Yang, PhD, associate professor of Urology, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study published in Nature Communications. Long-read RNA sequencing technologies have transformed transcriptomics research by detecting complex RNA splicing and gene fusion events that have often been missed by conventional short-read RNA-sequencing methods.

A new PhD track is being added to the Walter S. and Lucienne Driskill Graduate Program in Life Sciences ( DGP) for the 2026 application cycle, to enhance student learning and build community around computational biology and bioinformatics at Feinberg. The computational biology and bioinformatics (CBB) track in the graduate program will prepare students through coursework and lectures to use modern computational approaches, including machine learning and artificial intelligence, to extract biological insight from large-scale datasets to address complex biological problems.

Martschenko's argument is largely that genetic research and data have almost always been used thus far as a justification to further entrench extant social inequalities. But we know the solutions to many of the injustices in our world-trying to lift people out of poverty, for example-and we certainly don't need more genetic research to implement them. Trejo's point is largely that more information is generally better than less.

Biology is undergoing a transformation. After centuries of studying life as it evolves naturally, researchers are now using a combination of computation and genome engineering to intervene, generating new proteins and even whole bacteria from scratch. The use of artificial-intelligence tools to design biological components, an approach known as generative biology, is set to turbocharge this area of research. Just last year, scientists used AI-assisted design to produce artificial genes that can be expressed in mammalian cells.