The collision occurred around 4:50 a.m. at Bathurst and Eglinton, leading to several injuries, including one man in his 20s in serious condition.
The passenger vehicle was on fire when fire crews arrived, and a passerby may have rescued the occupant before paramedics arrived.
Toronto police are investigating the crash circumstances, including the possibility that one of the vehicles ran a red light at the intersection.
The intersection remained closed for police investigation, with the TTC announcing detours for the 7 Bathurst bus and disrupted service in the area.
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