A study in Wales investigated the link between shingles vaccination and dementia rates, contrasting individuals born before and after September 2, 1933. Results indicated that those eligible for the vaccine experienced a 1.3% decline in dementia risk, equating to an 8.5% drop in relative incidence. Notable was the confirmation of the vaccine's efficacy in lowering shingles rates, and similar analyses reaffirmed these findings, suggesting a real protective effect against dementia possibly attributable to immune function improvements as well as direct suppression of the varicella zoster virus.
The study found a 1.3 percent reduction in absolute risk of dementia diagnosis among those eligible for the shingles vaccine, translating to a substantial relative risk reduction.
The researchers' findings suggest that the shingles vaccine, alongside safeguarding against shingles, may also have a beneficial effect on reducing dementia incidence.
The evidence presented supports the hypothesis that suppressing the varicella zoster virus could potentially delay or reduce the onset of dementia.
Using a robust difference-in-difference approach, researchers eliminated confounding factors, widely suggesting the protective effect of the shingles vaccine on dementia.
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