Inflammation, while crucial for defense against threats, can become harmful if prolonged. The activation of immune responses may lead to psychiatric illnesses, including depression.
As inflammation alters the blood-brain barrier, cytokines infiltrate the brain, triggering changes that can manifest as depression. This disruption assists in understanding mental health conditions.
Research indicates that elevated levels of pro-inflammatory markers in the peripheral nervous system are connected to depression, showing this relationship exists, regardless of physical illnesses.
Studies suggest that inhibition of inflammatory proteins can alleviate depression-like behavior in experimental models, hinting at the potential for anti-inflammatory drugs to treat resistant depression.
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