The research found that fat cells have a biological 'memory' of past obesity, striving to return to this state even after weight loss.
Our study indicates one reason why maintaining body weight after initial weight loss is difficult. It means that one would have to 'fight' this memory to maintain body weight.
Genetic changes active in obesity group's fat cells were observed long after weight-reduction surgery, indicating a lasting molecular memory due to epigenetic changes.
In mice, we observed that formerly obese mice regain weight faster than those that were never obese, revealing different nutrient storage responses.
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