Researchers have uncovered that mutant RAS genes not only drive tumor growth at the cell surface but also influence processes within the nucleus, leading to uncontrolled growth.
Dr. Douglas Lowy highlighted the significance of this study, stating, 'This is the first study to show that mutated RAS genes can promote cancer in an entirely new way,' indicating a novel pathway for potential treatments.
The study also points out that current RAS inhibitors, while a breakthrough, have limited effectiveness in improving patient outcomes, as they mainly extend survival by a few months.
The discovery that mutant RAS directly influences the nuclear protein EZH2 is a crucial finding, suggesting new avenues for therapeutic intervention in RAS-driven cancers.
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