A four-year-old girl underwent experimental CAR T-cell therapy for nerve-cell cancer at Texas Children's Hospital after standard treatments failed. Nineteen years on, she is cancer-free and a mother of two, marking the longest remission reported after CAR T treatment. While CAR T-cell therapies have gained FDA approval for blood cancers, their effectiveness against solid tumours remains challenging. Researchers are optimistic that the success case will inspire further advancements, particularly in treating solid tumours like neuroblastoma.
This provides me with a lot of hope. We're going to unlock CAR T cells for people with solid tumours.
This is some kind of weird synthetic biology. Will it actually work?
Seven CAR-T-cell therapies have been approved by the US Food and Drug Administration since 2017.
The remarkable success story is the longest reported cancer remission following treatment with engineered immune cells called CAR T cells.
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