Bosa has been sidelined since a third-quarter oblique strain Nov. 17 against Seattle, while Williams' hiatus is mainly due to an ankle injury and personal issues.
Charvarius Ward did not practice Friday due to a personal matter; he played last Sunday in Buffalo in his first game since the death of his daughter.
The 49ers move past last Sunday's season-ending injuries to Christian McCaffrey and Jordan Mason as they prepare for the game against the Bears.
Purdy had no setbacks in his return at Buffalo and is full-go after missing the loss to Green Bay due to a shoulder injury.
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