The 49ers' offense provides a unique challenge for defenses with versatile players like McCaffrey and Samuel who can switch roles between running back and wide receiver.
With both McCaffrey and Samuel unavailable, the 49ers will rely heavily on Jordan Mason to carry the offensive load against the Rams, aiming to keep drives alive.
Jake Brendel, despite being the lowest-graded offensive lineman, is crucial to the team's success against the Rams and must show continued improvement and sturdiness.
The 49ers, looking to rebound from a disappointing performance against the Vikings, will face a critically weakened Rams team, still searching for their first win of the season.
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