Sheila Dodge is a molecular biologist who managed genomics data production at the Broad Institute of Harvard and MIT in Cambridge, Massachusetts. The institute, founded as a Harvard-MIT collaboration and an outgrowth of the Human Genome Project, aims to analyze genetics of diseases like cancer and schizophrenia by comparing DNA sequences of affected and unaffected people to find causative anomalies. Sheila was promoted to integrate three data-production groups into a cohesive organization while ensuring the lab remained technologically leading. The lab builds a large reserve of genetic data to elucidate human biology and to transform medical practice through improved diagnosis, treatment selection, and prevention. Gene sequencing changes rapidly, with costs falling faster than in many other technologies.
"We are trying to understand what causes disease in people," Sheila explained to us. "We spend a lot of time and effort building up a reserve of genetic data, and we use those data to try to elucidate what's going on in the human body. Our goal is to transform how medicine happens: How doctors interact with patients, how they understand which drugs to give people, and how they prevent and treat disease."
the Broad Institute of Harvard and MIT located in Cambridge, Massachusetts. Established in 2004 as a Harvard-MIT research collaboration, the institute was an outgrowth of the Human Genome Project. Its main goal was the genetic analysis of diseases, including cancer and schizophrenia, that did not always respond to conventional treatment. By comparing the DNA sequences of people who had the disease to those who did not, the institute hoped to identify the genetic anomalies that were responsible.
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