The APOE ε4 gene variant heightens the risk for Alzheimer’s disease and other age-related brain disorders, such as Parkinson's disease and motor neuron disease. Utilizing the Global Neurodegeneration Proteomics Consortium database, researchers analyzed proteomics data from over 11,000 individuals, revealing that APOE ε4 influences a wide array of neurodegenerative conditions beyond Alzheimer's. The study emphasizes the significant role of chronic inflammation mediated by APOE ε4 in these diseases. This variant produces specific protein profiles which are linked to various neurological disorders affecting millions globally.
The gene variant APOE ε4 not only increases the risk of late-onset Alzheimer's disease but also contributes to various age-related brain disorders including Parkinson's disease and motor neuron disease.
Researchers utilized the Global Neurodegeneration Proteomics Consortium data set comprising samples from over 18,600 individuals to analyze the impact of the APOE ε4 variant on multiple neurodegenerative diseases.
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