Capturing dynamic phage-pathogen coevolution by clinical surveillance - Nature
Phage-inducible chromosomal island-like elements (PLEs) in Vibrio cholerae provide defense against ICP1 phage predation, influencing pandemic strain evolution and disease severity through dynamic phage-bacteria interactions.
Scientists discover clue in viruses that reveal if they were lab-made
A new study analyzing seven viral outbreaks found no unusual genetic changes in Covid or most viruses before emergence, supporting a natural zoonotic origin rather than lab creation.
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor - Nature
Marburg virus causes 73% case fatality rate in humans with no licensed therapeutics or vaccines available, unlike Ebola virus which has approved treatments and vaccines despite lower mortality.
Researchers engineered Clostridium sporogenes bacteria to consume tumor cells from inside, offering a potential alternative to traditional cancer treatments.
A membrane-bound nuclease directly cleaves phage DNA during genome injection - Nature
SNIPE is a membrane-bound nuclease defense system in bacteria that directly targets foreign nucleic acids to prevent phage infection through a novel mechanism distinct from established defense pathways.
The infection enigma: why some people die from typically harmless germs
Genetic mutations in immune-related genes cause inborn errors of immunity that make some people uniquely vulnerable to severe infections and immune disorders.