Compared with people who reported drinking no coffee, those reporting 3-4 cups per day had longer telomeres, while those reporting 5 or more cups per day did not show the same association.
The AI analysis found enormous variation in the health of the thymus between individual people. In some people, it stayed very active until a very old age. And other people, it actually declined very rapidly at a younger age. Importantly, thymus health correlated with a person's overall health. People who had a healthy thymus tended to live longer, have less cancer, and less cardiovascular disease.
Asexual reproduction is ultimately unsustainable for mice, and potentially other mammals, too. The clones looked normal and lived as long as normal mice. But large mutations - including the loss of an entire chromosome - accumulated in the cloned lineage at an unusually high rate.
The Israeli gerontologist has been studying healthy centenarians for years and has observed that many follow a pattern similar to Reichert's. They do not always lead a monastic, carefully balanced life. There is a great deal of biological lottery involved in longevity. But Barzilai wants to hack that lottery—to understand which numbers are the winning ones and pass them on to the rest of humanity.
Your brain is like a muscle that only gets stronger when challenged with variety. Feed it the same mental diet every day, and it atrophies. The sharp elderly people in her studies had one thing in common—they deliberately sought intellectual discomfort. This doesn't mean forcing yourself through content you hate. It means breaking patterns.
Researchers administered one of four doses of stem cells to 118 people between 70 and 85 years old, all of whom had frailty. In a timed walking test nine months after treatment, those who had received the highest dose could walk about 60 metres farther, on average, than they could before treatment.
"As we get older, the immune system is shifting away from good inflammation," which is the body's short-term, acute response to fend off injury or infection and promote healing, explains Dr. Thomas Marron, one of the researchers leading the new study. Marron directs early phase clinical trials at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai.
Dementia is linked to changes in the brain. Health professionals used to assume that brain damage and dementia symptoms always went hand in hand. More recent research, however, shows that some people have significant brain damage yet never develop dementia. How can that be? In a previous post, I shared that dementia is defined by the inability to function in everyday life, such as getting lost in familiar places, having difficulty managing finances, forgetting to turn off the stove, or struggling with basic tasks.
Even though you're working out hard, you're just not seeing loss of fat and increase in muscle. Based on his own research and experience, TRT can be almost as significant for middle-aged people as eating protein-rich whole foods or moving enough throughout the day, as testosterone starts declining for most people in their 30s, with more notable symptoms appearing around their 40s or 50s.
