Compared with people who reported drinking no coffee, those reporting 3-4 cups per day had longer telomeres, while those reporting 5 or more cups per day did not show the same association.
If you're going to prioritize one thing for your brain health, make it this: regular aerobic exercise. Multiple large-scale studies show that aerobic exercise doesn't just keep your heart healthy-it directly impacts your brain structure. One year of aerobic exercise in older adults led to significantly larger hippocampal volumes and better spatial memory. Other trials documented that exercise actually slows age-related gray matter volume loss.
It might come as a surprise to learn that the brain responds to training in much the same way as our muscles, even though most of us never think about it that way. Clear thinking, focus, creativity, and good judgment are built through challenge, when the brain is asked to stretch beyond routine rather than run on autopilot. That slight mental discomfort is often the sign that the brain is actually being trained, a lot like that good workout burn in your muscles.
Betley and his colleagues were curious about what happens in the brain as people get stronger through exercise. They decided to focus on the ventromedial hypothalamus, a brain region that regulates appetite and blood sugar. The team then zeroed in on a group of neurons in that region that produce a protein called steroidogenic factor 1 (SF1), which is known to play a part in regulating metabolism. A previous study found that the deletion of the gene that codes for SF1 impairs endurance in mice.